The Athena Hotel Siena is located in a quiet area of downtown Siena, within walking distance of several of the city's premier attractions, including the cathedral and the Piazza del Campo. Located in the center of Siena, the Athena Hotel Siena is close to public transportation, and it is within easy walking distance of many of the city's main attractions.

Each of the Athena Hotel Siena's one hundred rooms is decorated in a slightly different manner, but they are all either modern or classical, and every room features plenty of natural lighting. Each room has a minibar and a safe, a private bathroom, and air conditioning.

This large hotel features a terrace on the seventh floor that is used during the summer months for bar and restaurant seating. The Athena Hotel Siena includes a meeting room large enough to house eighty people at a convention or business meeting, and its restaurant, which serves local cuisine and international treats, can also seat eighty people.